The national toxicology program ntp is formed from parts of several different us government agencies including the national institutes of health nih the centers for disease control and prevention cdc and the food and drug. But when asbestos dust is inhaled or ingested mineral fibers can become permanently trapped in the body.
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Serpentine asbestos and amphibole asbestos.
How do asbestos fibres cause mesothelioma. The connection between asbestos exposure and mesothelioma was discovered in the 1970s. Mesothelioma is almost exclusively caused by asbestos exposure. Iarc classifies asbestos as carcinogenic to humans based on its ability to cause mesothelioma and cancers of the lung larynx voice box and ovaries.
Some of the fibres can be coughed up and. Asbestos minerals are divided into two major groups. Over many years these fibres can cause pleural mesothelioma or other lung conditions to develop.
Mesothelioma accounts for less than 1 of all cancers diagnosed in the uk around 2600 people were diagnosed with the disease in 2011 and it is the seventeenth most common cause of cancer death around 2400 people died in 2012. The asbestos fibres can also travel through the lung tissue and settle in the outer lining of the lung the pleura. Asbestos fibres can also be swallowed and some of the fibres can get stuck in the digestive system.
Asbestos is an effective insulator and it can be used in cloth paper cement plastic and other materials to make them stronger. Asbestos is made up of tiny fibres. The asbestos fibers cause irritation in the tissue which leads to the formation of scar tissue and inflammation.
Mesothelioma can develop as a result of dna damage caused by the fibers. The damage can cause the cells to divide abnormally thus becoming cancerous. It can be present today in any building built or refurbished before the year 2000.
When these fibres are inhaled they can cause serious diseases. Asbestos exposure is the only proven cause of mesothelioma. Once the asbestos fibers are in the mesothelium there are two main theories about how they cause cancer.
They irritate the pleura and may cause gene changes mutations that lead to the growth of cancer. You can breathe these fibres in when you come into contact with asbestos. Chrysotile asbestos is the form that has been used most widely in commercial applications.
Serpentine asbestos includes the mineral chrysotile which has long curly fibers that can be woven. However there are other factors and pre existing conditions that could increase risk. When inhaled or ingested the fibers may become lodged within the lining of the internal organs leading to cancer.
The asbestos fibers bind with cells and damage them. However asbestos is not just a problem of the past. How asbestos causes mesothelioma.
When materials that contain asbestos are disturbed or damaged fibres are released into the air. The fibres work their way into the pleura lining the lung. The cancer doesnt usually cause symptoms until 20 to 50 years after exposure to.
Over decades trapped asbestos fibers can cause inflammation scarring and eventually genetic damage. Once asbestos is inhaled the body has a hard time getting rid of the fibers.
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