Amatuximab is a chimeric monoclonal antibody that binds to mesothelin. Mesothelin is an emerging cell surface target in mesothelioma and other solid tumors.
Amatuximab Overview Creative Biolabs
Most antibody drug candidates recognize highly immunogenic region i 296390 on mesothelin.
Amatuximab mesothelioma. On september 28 2012 amatuximab a drug designed to help treat patients with mesothelioma received orphan drug status from the fda. Amatuximab is a chimeric monoclonal antibody to mesothelin a cell surface glycoprotein highly expressed in malignant pleural mesothelioma mpm. Amatuximab is a chimeric monoclonal antibody to mesothelin a cell surface glycoprotein highly expressed in malignant pleural mesothelioma mpm.
Amatuximab was developed by morphotek inc. On the basis of its synergy with chemotherapy in preclinical studies we evaluated the antitumor activity of amatuximab plus pemetrexed and cisplatin in patients with unresectable mpm. Amatuximab was studied in a phase ii trial in mpm demonstrating a safety profile of amatuximab in combination with pc consistent with that seen previously for the pc regimen alone.
The immunotherapy drug amatuximab morab 009 targets mesothelin proteins which tend to be overexpressed by tumor cells in mesothelioma and other cancers. The fda has approved amatuximab to treat patients with malignant pleural mesothelioma the most common form of mesothelioma sometimes referred to as meso for short. The drug is a mouse human chimeric monoclonal antibody with a selective affinity for msln mesothelin 6.
Although the artemis trial is still ongoing the newest published study on amatuximab examines the way the drug moves through the bodies of patients with unresectable malignant mesothelioma and its effect on their overall survival. In more detail amatuximab morab 009 is a monoclonal antibody designed to target mesothelin a cell surface glycoprotein associated with cell adhesion that is overexpressed in certain types of cancer including. Although pfs was not significantly different from historical.
Amatuximab is also known as anti mesothelin monoclonal antibody morab 009amatuximab is an anti mesothelin monoclonal antibody morab 009 binds to mesothelin a protein that is made by some cancer cells and stops the cells from dividing and also called morab 009. Amatuximab is a chimeric monoclonal antibody designed for the treatment of cancer. Based on its synergy with chemotherapy in pre clinical studies we evaluated the antitumor activity of amatuximab plus pemetrexed and cisplatin in patients with unresectable mpm.
Testing amatuximab for pleural mesothelioma. Researchers at the european knowledge centre ekc and the national cancer institute working collaboratively showed that a higher amatuximab dose in malignant pleural mesothelioma mpm patients was associated with longer overall survivalthe study suggested investigating if more frequent dosing might improve overall survival in this patient group. Orphan drug status simply means a potential drug has received a grant from the fda to help test the drug in treating rare diseases upon the request of a sponsor.
Mesothelin is highly expressed in epithelioid mesothelioma. Here we report.
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